Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial disease models
We are pleased to announce that Professor Xingguo Liu from Guangzhou Institutes of Biomedicine and Health, China and Director of Institute of Development and Regeneration will join Targeting Mitochondria 2026 as a speaker and give a presentation entitled "Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial disease models".
Summary:
Mitochondrial transplantation holds significant potential for mitochondrial diseases treatment. However, how to efficiently deliver exogenous mitochondria to somatic cells or tissues is still unsolved. We present a mitochondrial transplantation approach to deliver mitochondria into cells, mouse and monkey tissues with high efficiency, based on encapsulating mitochondria with vesicles derived from plasma membrane of erythrocytes. Treatment with encapsulated mitochondria complemented the loss, deletion or mutation of mitochondrial DNA, thereby rescuing the associated bioenergetic and biochemical defects in patient-derived cells with mitochondrial disorders.
Furthermore, mitochondrial capsules rescued the mitochondrial DNA depletion syndrome and Leigh syndrome in Dguok-/- and Ndufs4-/- mouse models, respectively. Moreover, in a mouse model of Parkinson’s disease, mitochondrial capsules rescued neuron loss, improved motor skills and restored mitochondrial function in the affected brain regions. Our study demonstrates the potential of this mitochondrial capsule as a treatment for mitochondrial disorders, and proposes an “organelle therapy” strategy in regenerative medicine.
Recent Research:
Professor Xingguo Liu's recent research has been highlighted in the World Mitochondria Society. To read the article, click here
