Novel movies showing lipid droplets and mitochondria fine dynamics live and at high resolution

During the Targeting Mitochondria 2019 Congress, Holotomographic Phase Imaging or short Nanolive Imaging will be presented at the Targeting Mitochondria with a talk and booth.

Non-invasive live cell imaging overcomes phototoxicity problem while imaging cellular and mitochondrial processes

Mitochondria are key organelles for various essential cellular processes.

Symposium Actin(g) on mitochondria: The role of actin-regulating proteins on mitochondria in health and disease

10th Anniversary of Targeting Mitochondria Congress
October 28-29, 2019 - Berlin, Germany

Cytoskeletal mitochondrial interactions in collagen VI related disorders

The Scientific Committee of WMS is honored to announce that Dr. Alessia Angelin from Children's Hospital of Philadelphia, USA will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

During the Congress Dr. Angelin will speak about "Cytoskeletal mitochondrial interactions in collagen VI related disorders".

Summary of presentation:"Mitochondria are prominent players in cell energy conversion, integrated signaling pathways, calcium homeostasis and regulation of apoptosis. Their functional versatility is matched by their morphological plasticity and by their high mobility, allowing their transport to specialized cellular sites. This transport occurs through interactions with a variety of cytoskeletal proteins that also influence shape and function of this organelle. Our study focuses on the correlation between mitochondrial function and cytoskeleton structure. We found that improper cytoskeleton filament organization appears to connect the altered extracellular matrix with the mitochondrial dysfunction in collagen VI related disorders, and thus may present a new target for pharmacological therapy of these disorders and other human muscular dystrophies".

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Microbiota-Mitochondria Intertalk: A Dedicated session

During the Targeting Mitochondria, a session will be chaired by Prof. Marvin Edeas, University Paris Descartes, INSERM U1016, France, concerning the hot topics 2019: Microbiota-Mitochondria Intertalk.

Two Talks will be presented during this dedicated session: 

Mitochondria & Microbiota Inter-talk: Gut Microbiota inflence Mitochondria activity in patients
Marvin Edeas, University Paris Descartes, INSERM U1016, France

Host mitochondria influence gut microbiome diversity: A role for ROS
Tal Yardeni, Children's Hospital of Philadelphia, USA

Summary of Dr. Yardeni's presentation: "Changes in the gut microbiome are linked with the same diseases as those caused by changes in the mitochondrial genome. To investigate why, we tested the gut microbiome community of our mitochondrial mouse models. These studies reveal that the host mitochondrial ROS production influences the gut microbiome community. Our data suggest that mitochondrial function modulates both ROS production and the microbiome, implying that the connection between the gut microbiome and common disease might be due to changes in mitochondrial function."

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

2,4-Dinitrophenol as Medicine

The Scientific Committee of Targeting Mitochondria 2019 congress invited Dr. John G. Geisler from Mitochon Pharmaceuticals, Inc, USA to talk about his research on "2,4-Dinitrophenol as Medicine" during the 10th Anniversary of Targeting Mitochondria Congress, which will be held in Berlin, Germany, on October 27th – 29th, 2019.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Targeting Mitochondria 2019 Congress will be held Hotel InterContinental

 Budapester Straße 2, 10787 Berlin, Germany

 *****

Hotel Booking with preferential rate is closed after October 7th.

Special Rate for Room Booking at Intercontinental Berlin Hotel

The upscale InterContinental® Berlin hotel sits next to leafy Tiergarten Park, pleasant walk from the iconic Brandenburg Gate. Choose an elegant room or spacious suite, swim in the inviting indoor pool and indulge in a treatment at SPA InterContinental. Entertaining clients in style on a dedicated meeting floor or making an impression with a function in the ballroom. After work, sip cocktails in the Marlene Bar and experience gourmet dining in a chic 14th-floor restaurant with panoramic city views. Targeting Mitochondria Committee offers to the congress attendees a special privileged rate for your booki:
Follow this link to book your Hotel

The challenge of qualitative and quantitative assessment of mitochondrial function

Dr. Egbert Mik will overview the perspective related to Mitochondria Evaluation in vitro, in vivo and human

Dr. Egbert Mik from the Department of Anesthesiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019

Dr. Mik will present the last methods (qualitative and quantitative assessment of mitochondrial function) and What we know in 2019 ?

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Mitochondrial Copper Toxicity with a Focus on Wilson Disease

Prof. Hans Zischka from Institute of Molecular Toxicology and Pharmacology, Germany will present his team's research during the congress and will give a talk entitled "Mitochondrial Copper Toxicity with a Focus on Wilson Disease".

Summary of Talk: Wilson disease (WD) is a hereditary defect in the metabolism of copper. Here, the liver is unable to eliminate excess copper causing its accumulation primarily in liver and brain. In neurons and hepatocytes, a rising copper overload particularly damages their mitochondria. However, sometimes years pass before cell death occurs, suggesting the possible existence of intracellular protective mechanisms that can counteract such mitochondrial poisoning.

Therefore, we examined cell cultures from WD patients but also WD rodent models for their reaction to copper. We observed that the hepatocytes reacted to copper overload with an intensification of the mechanisms that support autophagy. Particularly, the copper-overloaded mitochondria are affected by this process (in this case called mitophagy). However, mitophagy helps only up to a certain level of copper overload and other treatments need to be employed to avoid cell death. Nevertheless, these results demonstrate the potential for cell regeneration resulting from auto-/mitophagy, which could also be relevant for other disorders that arise or are paralleled by cell-toxic metal accumulations.

For more information: https://targeting-mitochondria.com

Mitochondria, as central regulators of neural stem cell fate

The Scientific Committee of WMS is honored to announce that  Dr. Ruth Slacks from University of Ottawa, Canada will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Dr. Slacks will give a presentation entitled "Mitochondria, as central regulators of neural stem cell fate".

For more information: https://targeting-mitochondria.com

The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain

Dr. Laurent Chatre will  introduce "The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain".

Dr. Laurent Chatre from CNRS, the University of Caen-Normandie, France will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Summary of presentation: From brain functions to brain hypoxia, ischemia, inflammation and cancer, Dr. Chatre will discuss their starting brain MITOxy project positioningt he coordination between mitochondria, proteases including serine proteases and the reactive species interactome (RSI)as the key regulator involved in normal and pathological conditions, and to control in the future.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Mitochondrial Antioxidant Therapy for Treating Vascular Aging

Prof. Seals will give a strategic talk on "Mitochondrial Antioxidant Therapy for Treating Vascular Aging".

The Scientific Committee of Targeting Mitochondria 2019 Congress is honored to announce Prof. Douglas R Seals from University of Colorado Boulder, USA will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Summary of the Talk:  Arterial dysfunction is the major risk factor driving the dramatic increase in risk of cardiovascular diseases with aging.  Excessive superoxide production by mitochondria is a key mechanism underlying age-related vascular dysfunction and, as such, is a major therapeutic target for prevention of cardiovascular disorders.  I will discuss our translational research efforts to establish the efficacy of the mitochondrial antioxidant, MitoQ, for the treatment of arterial dysfunction with aging.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Increased Hydrogen Peroxide and Decreased Glutathione Redox Potential May Cause Dopaminergic Neurodegeneration in Parkin Loss-of-Function Drosophila

The Scientific Committee of WMS is honored to announce that Dr. Lori Buhlman, Associate Professor from the College of Graduate Studies of Midwestern University, USA, will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

In her presentation entitled "Increased Hydrogen Peroxide and Decreased Glutathione Redox Potential May Cause Dopaminergic Neurodegeneration in Parkin Loss-of-Function Drosophila", Dr. Buhlman will discuss with us her recent studies on the mechanism of selective neurodegeneration in familial Parkinson’s disease. They use parkin loss-of-function Drosophila, which have selective dopaminergic neurodegeneration and motor behavior deficits.  "We have observed that degenerating neurons have transiently decreased mitophagy initiation, disrupted mitochondrial dynamics and increased mitochondrial protein oxidation, none of which were detected in non-degenerating dopaminergic neurons. Current goals are to understand important differences between vulnerable and non-degenerating dopaminergic degeneration in adult and developing flies and use genetic and pharmacological interventions to address them."       

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

The cellular stress protein MNRR1/CHCHD2 and mitochondrial disease

Prof. Lawrence Grossman from Wayne State University, USA will join the Targeting Mitochondria 2019 congress and will give a talk entitled "The cellular stress protein MNRR1/CHCHD2 and mitochondrial disease".

Summary of talk: MNRR1 is a key mitochondrial stress regulator with the novel property of functioning in both the nucleus and the mitochondria yet having a different function in each organelle. Because cellular depletion of MNRR1 results in a phenocopy of some mitochondrial diseases, we investigated whether manipulating MNRR1 expression could reverse the cellular defects associated with them. Notably, in a model of the mitochondrial disease MELAS we could restore abnormal cellular functions by forced expression of MNRR1 or by its activation.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Mitochondrial reactive oxygen species in heart failure

Prof. Christoph Maack from University Hospital Würzburg, Germany will join the Targeting Mitochondria 2019 Congress and  present his research work entitled  "Mitochondrial reactive oxygen species in heart failure".

The heart consumes large amounts of energy through the processes of excitation-contraction (EC) coupling in cardiac myocytes. To match energy supply to demand, mitochondria take up Ca²⁺ via the Ca²⁺ uniporter (MCU), where Ca²⁺stimulates rate-limiting enzymes of the Krebs cycle. The main products of the Krebs cycle, NADH and FADH₂, donate electrons to the electron transport chain (ETC) to build up the mitochondrial membrane potential (DY_m) that is the driving force for ATP production. Furthermore, Ca²⁺-induced Krebs cycle stimulation also regenerates NADPH for the antioxidative capacity of the mitochondrial matrix. 

Prof. Maack will highlight exactly what we obserse in heart failure during the Targeting Mitochondria Congress.

For more information about Targeting Mitochondria 2019: www.targeting-mitochondria.com

Mitochondria & Microbiota Inter-talk: Gut Microbiota influence Mitochondria activity in patients

During the Targeting Mitochondria, a session will be chaired by Prof. Marvin Edeas, University Paris Descartes, INSERM U1016, France, concerning the hot topics 2019: Microbiota-Mitochondria Intertalk. 

Mitochondria & Microbiota Inter-talk: Gut Microbiota inflence Mitochondria activity in patients
Marvin Edeas, University Paris Descartes, INSERM U1016, France

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com