DOI Assignment for Targeting Mitochondria 2024 Abstracts

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We are pleased to announce that all abstracts submitted this year to the 15th Annual meeting of the WMS will be included in the Targeting Mitochondria 2024 Abstracts Book, which will be assigned a DOI (Digital Object Identifier). This ensures your work will have a permanent and easily accessible online presence.

Importance of DOI

Having a DOI means your abstracts will be indexed on major academic platforms such as ORCID, Google Scholar, Scopus and others. This not only enhances the visibility of your research but also facilitates easy citation and sharing within the scientific community.

Abstract Submission Details

You can submit your abstracts here: www.wms-site.com/abstract submission

World Mitochondria Society 2024 Keynote Speaker Day 1: Prof. Eric Schon

Eric SchonWMS is happy to welcome Prof. Eric Schon from Columbia University, USA, as a keynote speaker on Day 1 of Targeting Mitochondria 2024 in Berlin this October. 

Prof. Schon will deliver a presentation titled "Mitochondria in Alzheimer disease: it's not what you think"

The dominant hypothesis of Alzheimer disease (AD) pathogenesis invokes the accumulation of a cleavage product of the amyloid precursor protein (APP), called beta-amyloid, as the driver of pathogenesis. However, the poor track record of clinical trials based on this hypothesis suggests that other causes likely underlie the disease. We propose an alternative hypothesis in which a different APP cleavage product, called C99, is the main culprit, via its role as a regulator of cellular cholesterol metabolism. In AD, both C99 production and cellular cholesterol levels are increased well above normal levels, resulting in essentially all of the biochemical and clinical features of the disease. From this perspective, AD is, at bottom, a lipid disorder.

About Eric Schon

Eric Schon, a professor of Neurology and Genetics, has focused on the intricacies of mitochondrial genetics, highlighting their unique semi-autonomous nature governed by both nuclear and mitochondrial DNA. Mitochondria, once bacteria, contribute to cellular energy production through oxidative phosphorylation. Schon's research explores various inherited and sporadic mitochondrial disorders, employing innovative techniques like cytoplasmic hybrids. Recently, his focus shifted to Alzheimer's disease, uncovering heightened ER-mitochondrial communication as a potential key player in its pathogenesis, offering insights into diagnosis and treatment.


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World Mitochondria Society 2024 Keynote Speaker Day 2: Prof. Howy Jacobs

Howy JacobsIt is with great pleasure that we welcome Prof. Howy Jacobs from Tampere University, Finland, as a keynote speaker on Day 2 at Targeting Mitochondria 2024 in Berlin this October. 

Prof. Jacobs has documented "A century of mitochondrial research, 1922–2022" in the Enzymes Book Series (2023). The chapter discussed the comprehensive research history of mitochondria, starting from their initial recognition as resembling bacteria in 1922, to their integration into cell physiology today, highlighting major advances in various scientific fields such as biochemistry, genetics, pathology, and cell biology.

Keynote Speech: "Mitochondria: More Heat Than Light?"

"Mitochondria are not just producers of ATP or clearing houses of intermediary metabolism. Here I will trace the history of how mitochondria have come to be regarded as key contributors to cell and organismal physiology, and how recent findings have opened up new chapters in our thinking" stated Prof. Jacobs.

Prof. Jacobs will discuss the implications of elevated mitochondrial temperature for evolution, development, cell signaling, immunity and pathology.

© Photo Credits: Rami Hanafi 


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Mitochondrial Extracellular Vesicles: Orchestrating Brain Plasticity and Recovery

Stefano PluchinoProf. Stefano Pluchino, University of Cambridge, United Kingdom, will be joining Targeting Mitochondria 2024 this October in Berlin. 

Prof. Pluchino will be sharing his latest research on the role of mitochondrial extracellular vesicles in brain plasticity and recovery, during the session dedicated to "Emerging Trends and Strategies in Mitochondria Research".

In his talk Prof. Pluchino will cover the the following:

  1. Extracellular vesicles from neural stem cells transfer IFN-g via Ifngr1 to activate Stat1 signalling in target cells
  2. Extracellular vesicles are independent metabolic units delivering functional Asparaginase-like protein 1n
  3. NSCs deliver functional mitochondria to target cells via EVs

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Mitochondria Delivery via Extracellular Vesicles to the Blood-Brain Barrier

Devika S ManickamDr. Devika S Manickam, Duquesne University, USA, and active member of the WMS Scientific Committee will be joining Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: Mitochondria Delivery via Extracellular Vesicles to the Blood-Brain Barrier

Highlights

  • Role of extracellular vesicles (EVs) in intercellular communication and drug delivery.
  • Incorporation of mitochondria small EVs (<200 nm) and medium-to-large EVs (m/lEVs >200 nm) EVs during biogenesis.
  • Potential of m/lEVs to deliver healthy mitochondria for treating neurodegenerative, cardiovascular, and metabolic diseases.
  • Advantage of m/lEVs using endogenous mechanisms for cellular repair.
  • Impact of ischemic stroke on mitochondrial function in blood-brain barrier endothelial cells.
  • Efficacy of human brain endothelial cells (BEC) -derived mitochondria-containing EVs in mouse stroke models.
  • Improved therapeutic outcomes with species-specific EVs (mouse BEC-EVs) in stroke models.
  • Support for using m/lEVs to enhance therapeutic potential in preclinical studies.

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Mitochondrial Transplantation Mediates Improved Cellular Energy Metabolism, Restoration of Mitochondrial Function and Prevention of Cell Death

Mark KindyIt is a great pleasure to welcome Dr. Mark Kindy, U.S. Department of Veterans Affairs James A. Haley VA Hospital and University of South Florida, USA at Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: Mitochondria Iron Metabolism: Mitochondrial Transplantation Mediates Improved Cellular Energy Metabolism, Restoration of Mitochondrial Function and Prevention of Cell Death

In his talk Dr. Kindy will cover:

  1. Isolation and characterization of mitochondria
  2. Application of mitochondrial transplantation
  3. Reversal of cellular dysfunction
  4. Restoration of energy metabolism

Dr. Kindy is a collaboration partner of the WMS supporter 2024 "MitoSense". About Mitosense.

Targeting Mitochondria 2024 program.


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Cracking the Code of Aging: Exploring Mitochondrial Dynamics and Organelle Connections

Antetor Hinton 1It is a great pleasure to welcome Dr. Antentor Hinton, Vanderbilt University, USA, at Targeting Mitochondria 2024 this October in Berlin.

Presentation title: Cracking the Code of Aging: Exploring Mitochondrial Dynamics and Organelle Connections.

Highlights

  • Overview of the current understanding regarding mitochondrial structural changes during aging.
  • Summary of the altered structural changes that occur with age in cristae architecture and their impact on mitochondrial calcium signaling.
  • Implications of how aging modifies organelle contact communication.
  • Illustration of how the MICOS (mitochondrial contact site and cristae organizing system) complex influences physiology and metabolism throughout the aging process.

More information on Dr. Hinton's latest research.

WMS 2024 Speakers Lineup. 


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Blood-Based Marker: Mitochondrial DNA Damage in Parkinson’s Disease

Laurie SandersDr. Laurie Sanders, Duke University School of Medicine, USA, will be joining Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: Blood-Based Marker: Mitochondrial DNA Damage in Parkinson’s Disease

In this talk, Dr. Sanders will discuss the challenges in Parkinson's disease (PD) treatment and the need for better diagnostic tools. Mitochondrial dysfunction's role in PD's development will be highlighted, along with recent findings on mitochondrial DNA (mtDNA) damage. Dr. Sanders will introduce a PCR-based assay called MitoDNADX for quantifying mtDNA damage, showcasing its potential as a blood-based marker for PD. Preliminary results from patient studies and animal models will be presented, suggesting that this assay could aid in PD diagnosis and assessing the effectiveness of LRRK2 kinase inhibitors in treating the disease.


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The Role of Mitochondria in Zika Virus Propagation: Mechanisms of Immune Evasion and Inter-Cellular Transmission

Indira Mysorekar 1It is a great pleasure to welcome Dr. Indira Mysorekar, Baylor College of Medicine, USA, at Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: The Role of Mitochondria in Zika Virus Propagation: Mechanisms of Immune Evasion and Inter-Cellular Transmission.

Highlights

  • Mitochondrial dynamics in viral pathogenesis
  • Use of Tunneling nanotubes for infecting neighbouring cells and siphoning mitochondria to fuel infection

More information on Dr. Mysorekar's latest research.

WMS 2024 Speakers Lineup. 


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Dynamics of Mitochondria: Regulation of Nucleoid Morphology to Protect Mitochondrial Function

Naotada Ishihara 1Prof. Naotada Ishihara, Osaka University, Japan, will be joining Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: Dynamics of Mitochondria: Regulation of Nucleoid Morphology to Protect Mitochondrial Function.

Highlights

  • Discuss the connection between mitochondrial dynamics (fusion/fission) and the behavior of mtDNA nucleoids within the cell.
  • Mitochondrial membrane activity influences the shape and distribution of mtDNA nucleoids.
  • Abnormalities in both mitochondrial morphology and nucleoid structure are linked to certain diseases.
  • Expose the new methods to manipulate nucleoid structures, improving mitochondrial and cellular functions in some pathogenic conditions.

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New Biosensing Solutions and Optimized Pharmacological Inhibitors to Counteract Mitophagy in Cancer Cells

Giulia Bertolin 1It is a great pleasure to welcome Dr. Giulia Bertolin, Université de Rennes, France, at Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: New Biosensing Solutions and Optimized Pharmacological Inhibitors to Counteract Mitophagy in Cancer Cells

Highlights

  • Mitochondria play vital roles in cell physiology, and dysfunctions are implicated in diseases like cancer and neurodegenerative disorders.
  • Mitochondria are closely integrated with other cellular components, impacting functions such as cell cycle regulation and ATP production.
  • The talk will explore how cancer cells exploit mitochondrial functions, focusing on the cell cycle protein AURKA, which is often overexpressed in breast cancer.
  • Advanced fluorescence microscopy techniques are utilized to track AURKA activation in living samples, providing insights into its role in mitochondrial function.
  • Ongoing research aims to develop sensitive biosensors for monitoring mitochondrial activation of AURKA and exploring pharmacological inhibitors to alter its interaction with mitophagy partners.

WMS 2024 Speakers Lineup. 


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Mitochondrial Dynamics in Health and Disease: Advances in Mood Disorders and Mitochondrial-Organ Transplantation

Ana Andreazza 2 1It is a great pleasure to welcome Dr. Ana Andreazza, University of Toronto, Canada at Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: Mitochondrial Dynamics in Health and Disease: Advances in Mood Disorders and Mitochondrial-Organ Transplantation

Points to be covered:

1. Mitochondrial Dynamics in Health and Disease:
Explore the essential role of mitochondria in energy balance, neuronal signaling, and cellular health. Emphasize their influence on the brain and other critical organs, underlining the importance of mitochondrial health in overall bodily function.

2. Linking Mitochondrial Dysfunction to Mood Disorders:
Explore the relationship between mitochondrial dysfunction and mood disorders. Present clinical evidence showing their correlation and introduce cutting-edge mitochondrial-targeted metabolomics to improve patient classification and treatment paths.

3. Innovative Therapeutic Approaches:
Discuss advancements in mitochondrial transplantation and the creation of the MitoGENE risk score. These innovations aim to refine diagnostic and therapeutic strategies, supported by data from real-world clinical trials.

WMS 2024 Speakers Lineup. 


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Mitochondria and Photomedicine: Advances in Infrared Light Treatment

Maik Hüttemann 1

Prof. Maik Hüttemann, Wayne State University, USA, and active member of the WMS Scientific Committee will be joining Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: Mitochondria and Photomedicine: Advances in Infrared Light Treatment.

Highlights

 

  • Brain ischemia followed by reperfusion leads to neuronal death due to mitochondrial dysfunction.
  • Mitochondrial Dysfunction: Reperfusion causes hyperactivity in the electron transport chain, leading to cell death.
  • Current pharmacological treatments have limitations in effectiveness and timing.
  • Specific Near Infrared Light (IRL) wavelengths inhibit mitochondrial dysfunction noninvasively.
  • New waveguide technology was developed for safe and efficient IRL delivery into the brain.
  • IRL treatment reduces neuronal death in animal models.
  • Cytochrome c-COX-inhibitory IRL emerges as a promising non-pharmacologic, noninvasive therapy for cerebral ischemia/reperfusion injury.

 


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Mitochondria Iron Metabolism: Its Role in Pathogenesis of Diseases

Sonia Levi 1It is a great pleasure to welcome Dr. Sonia Levi, Vita-Salute San Raffaele University, Italy, at Targeting Mitochondria 2024 this October in Berlin. 

Presentation title: Mitochondria Iron Metabolism: Its Role in Pathogenesis of Diseases

In her talk Dr. Levi will cover the following:

  • Discuss the importance of iron in the physiology of mitochondria.
  • Mitochondria as the critical controllers of cellular iron homeostasis and their involvement in the mechanism of ferroptosis, an iron-dependent form of cellular death driven by lipid peroxidation.
  • Example of how mitochondrial iron-deficiency and -overload impair mitochondrial metabolism, promoting disease development.
  • Focus on mitochondrial iron-imbalance role in the initiation and progression of neurodegenerative diseases.

More information on Dr. Mysorekar's latest research.

WMS 2024 Speakers Lineup. 


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World Mitochondria Society Task Force: Call For Strategic Projects

We have the pleasure to announce the formation of the WMS Task Force, a groundbreaking initiative committed to driving innovation and reshaping the landscape of mitochondria research in health and diseases.

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The Aim of WMS Task Force

Through the establishment of a cooperative environment, this Task Force aims to address the challenges that impede the understanding, prevention and treatment of diseases related to mitochondria. It is a platform where knowledge and expertise are freely shared, fostering an atmosphere conducive to significant advancements in mitochondria research in health & diseases.

Our vision of establishing a Task Force that brings together multidisciplinary experts, which is crucial for pushing the boundaries of mitochondrial research and innovation. By fostering a collaborative environment, we can collectively address challenges, share knowledge and expertise, and drive advancements in the understanding of mitochondria research and related diseases.


WMS Task Force Projects

The WMS Task Force is launching 2 projects for the improvement of mitochondrial research and applications:

1- Mitochondrial Transfer & Tunneling Nanotubes (TNTs). Read more.

2- Mitochondrial Oscillation and Resonance: Impact on ATP Production and Distribution in Health and Diseases. Read more.


The Funding

In terms of funding, the WMS Task Force is prepared to submit the selected projects to both public and private institutions. The objective is to secure the necessary resources to fuel these projects, and ensure the sustainability and longevity of the task force.

The collected funding will be distributed to all teams invovled in the Task Force.


How to Join the Task Force & Structure your Project Proposal?

To contribute to one of these 2 pioneering projects, the WMS requests interested researchers and teams to submit a proposal detailing the following aspects:

· Project Overview:
Please provide a concise description of your current research or project. Include key goals, methodologies used, and any preliminary results or findings that could highlight the relevance and potential impact of your work.

· Alignment with Task Force Goals:
Articulate how your work contributes to the broader objectives of the task force. This could be in terms of techniques being developed, the specific aspects of mitochondrial transfer your project focuses on, or the potential applications of your research.

· Challenges and Solutions:
Identify any potential hurdles or obstacles you anticipate in the course of your research. This could be technical issues, logistical constraints, or theoretical problems. Additionally, provide an outline of how you propose to tackle these challenges. This shows proactive problem-solving and can help us better understand the feasibility of your project.

· Team Profile:
Furnish an overview of your team and its expertise. Highlight the skills, qualifications, and experiences of your team members that make them well-equipped to carry out the proposed project. Include any past achievements or relevant projects that demonstrate your team’s capacity to successfully execute the research.


How to Submit?

Please submit your projects and details above to:

· Prof. Volkmar Weissig, President of the WMS

· Prof. Marvin Edeas, Chairman of the Scientific Committee

- At the following email address: mitochondria(at)wms-site.com. 

- Deadline for the submission: June 30, 2024.  

Applications will be reviewed by the Task Force Selection Committee, and successful applicants will be contacted to proceed to the next stage of the process. Please note that acceptance into the task force is competitive, and only a select number of applicants will be chosen to join.

We look forward to your valuable input and collaboration in this groundbreaking endeavor.


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