Cardiorespiratory Fitness and Mitochondrial Health as Modulators of COVID-19
Dr. Johannes Burtscher, from University of Lausanne, Suisse will join the Targeting Mitochondria 2021 Congress and will give a presentation entitled "Cardiorespiratory Fitness and Mitochondrial Health as Modulators of COVID-19".
Dr. Burtscher confirms that some coronaviruses like SARS-CoV-2, the pathogen causing COVID-19, manipulate host cell mitochondria to dodge the host immune defense. We hypothesize that good mitochondrial health, for example due to regular exercise and associated with cardiorespiratory fitness, protects from viral manipulation of mitochondria. Conversely, mitochondrial damage may facilitate viral infection and aggravate the disease. I will summarize the theoretical interactions of SARS-CoV-2 with host mitochondria and provide an overview of recent studies investigating the link between COVID-19 and cardiorespiratory fitness and mitochondrial health.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Mitochondrial Arginase-2 is Essential for IL-10 Metabolic Reprogramming of Inflammatory Macrophages
Dr. Claire McCoy from Royal College of Surgeons in Ireland, Ireland will join the Targeting Mitochondria 2021 Congress and give a presentation about "Mitochondrial Arginase-2 is Essential for IL-10 Metabolic Reprogramming of Inflammatory Macrophages".
Dr. Claire McCoy graduated in Biochemistry from Trinity College Dublin and completed her PhD at the University of Dundee, Scotland in 2006. Her first postdoctoral position in Innate Immunology was completed at Trinity College Dublin, during which time she was awarded a prestigious Marie Curie International Fellowship. She joined the Hudson Institute, Melbourne as a Research Fellow in 2010 and obtained a New Investigator Project Grant from the NHMRC to continue her work investigating the role of microRNAs in Inflammatory diseases. Claire joined RCSI as the Immunology lecturer in August 2016, where she now leads the growing microRNA Inflammation research group. Claire was the recipient of an SFI Future Research Leader's award presented by President Higgins in January 2018.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
A session dedicated to Nuclear-mitochondrial interactions and their effect on longevity and health will be organized
A session dedicated to the "Nuclear-mitochondrial interactions and their effect on longevity and health" will be organized by Prof. Miria Ricchetti, Team Stability of Nuclear and Mitochondrial DNA, Institut Pasteur, France that will chair the session.
Among the speakers:
 Introduction & Presentation of SessionDr. Miria Ricchetti, Team Stability of Nuclear and Mitochondrial DNA, Institut Pasteur, France |
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Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Deciphering strategic interactions between mitochondrial and nuclear genome
Dr. José Antonio Enríquez from Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain. Dr. Enríquez will give a presentation entitled "Deciphering strategic interactions between mitochondrial and nuclear genome".
Dr. Enríquez has done probably the most advanced studies on nuclear-mitochondrial interactions and their effect on organisme longevity and health. He focuses on distinct combinations of nuclear and mitochondrial genomes and their effect at the organismal level (lifespan, health condition, predisposition to disease), as well as investigates the underlying mechanism including respiratory complexes and supercomplexes.
Last year he published a seminal paper in Science Advances showing the dynamics of non-pathogenic heteroplasmy (segregation of one of the two mtDNA genomes in different tissues) and their dependence on OXPHOS performance (PMID: 32832682). See also a recent review (PMID: 33369015) on the interactions between mitochondrial and nuclear genome.
Heteroplasmic mouse models harboring in the same cytoplasm, different non‐pathological mtDNA variants‐haplotypes. MtDNA preference is cell‐type‐specific and not tissue‐specific. Also, the metabolic differentiation program determines the preferred mtDNA haplotype and the mtDNA segregation is driven by functional selection and strongly modulated by the crosstalk between the nucleus and mitochondria. © 2020 The Authors. IUBMB Life
https://doi.org/10.1002/iub.2434
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com
Circulating Mitochondrial DNA as an Early Indicator of Severe Lung Disease
Prof. Andrew E. Gelman from Washington University School of Medicine, USA will give a presentation entitled "Circulating Mitochondrial DNA as an Early Indicator of Severe Lung Disease".
Prof. Gelman will discuss how cell-free mitochondria DNA levels have been used to evaluate the severity of solid organ injury. He will also cover the implications of cell-free mitochondrial DNA findings in several pulmonary diseases including COVID-19. Additionally, Prof. Gelman will talk about the possible tissue origins of cell-free mitochondria DNA and whether it is the result of an overexuberant immune response or a sign of mitochondrial dysfunction.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
The Bioenergetics Consequences of Winter Cold in Small Birds
Dr. Andreas Nord, researcher in evolutionary ecology at Lund University, Sweden, will present his study on "The Bioenergetics Consequences of Winter Cold in Small Birds".
Dr. Nord highlighted: "Small birds at high latitude face converging energetic challenges in winter, when low air temperature increases the energy cost of staying warm at the same time as short day length and snow constrain refuelling opportunities. The thermoregulatory adaptations that permit existence in such environments are well studied on organismal levels, but analogous processes in the cellular machinery fuelling thermoregulation are poorly understood. In this talk, I will outline how seasonal and diurnal changes in mitochondrial function interact with whole-animal physiology to help birds stay warm when it is cold".
Please follow this link to read detailed news on his research.
Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Glucose Metabolism Control of T Cell Immunity
Prof. Ming Li, from Immunology Program, Memorial Sloan Kettering Cancer Center, USA will give a presentation entitled "Glucose Metabolism Control of T Cell Immunity".
Prof. Ming Li is a Member of the Immunology Program at Memorial Sloan Kettering Cancer Center and Professor at Weill Cornell Graduate School of Medical Sciences. His laboratory studies immune regulation and its relevance to diseases including cancer. Recent work has focused on the signaling, metabolic, and transcriptional mechanisms of T cell regulation as well as tumor-elicited innate and adaptive immune responses, and how this knowledge can be translated for novel cancer immunotherapies. Dr. Li has received a number of honors including a Howard Hughes Medical Institute (HHMI) Faculty Scholar Award, a Rita Allen Foundation Scholar Award, an American Cancer Society Scholar award and the 2016 American Association of Immunologists (AAI)-BD Bioscience Investigator Award for outstanding contributions to the field of immunology.
Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Exercise-Induced, Mitochondrial-Mediated Cell Death in Arrhythmogenic Cardiomyopathy
Dr. Stephen Chelko from Department of Biomedical Sciences, Florida State University, USA will join the Targeting Mitochondria 2021 Congress which will be held on October 27-29, 2021 and will give a presentation on his recent work in Science Translational Medicine on the "Exercise-Induced, Mitochondrial-Mediated Cell Death in Arrhythmogenic Cardiomyopathy".
Arrhythmogenic Cardiomyopathy (ACM) is a familial heart disease with a high incidence of sudden cardiac death in the young and in athletes. Reduced penetrance and variable expressivity complicate early diagnosis and management of ACM. More and more evidence on the deleterious impact of exercise in ACM is growing, yet these studies all implicate the arrhythmic risk and/or hemodynamic load on the heart in response to exercise. New evidence demonstrates that endurance exercise leads to mitochondrial dysfunction, ROS generation, and large-scale myocyte death in ACM.
Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Mitochondrial DNA in Cancer: The Overlooked Oncogenome
Dr. Payam A. Gammage from CRUK Beatson Institute, United Kingdom will join the Targeting Mitochondria 2021 Congress and will present a talk entitled "Mitochondrial DNA in Cancer: The Overlooked Oncogenome" during the congress.
Dr. Gammage will discuss the mutations of mtDNA that have been detected in human cancers for some decades, although their impact on the disease has not been clear and any potential role of mitochondrial genetics in cancer has been broadly overlooked. To better understand the role of mtDNA in cancer we repurposed targeted clinical sequencing data to assemble the largest dataset of partially matched tumour-normal mtDNA sequences to date (>40,000 tumours). Using this resource he has, Dr. Gammage defined the pan cancer landscape of mtDNA mutations, demonstrating clear evidence of respiratory complex-specific mutational recurrence and selection alongside the impact of mtDNA mutations on patient survival.
Key Publications
Gorelick AN, Kim M, Chatila WK, La K, Hakimi AA, Berger MF, Taylor BS, Gammage PA, Reznik E. Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA. Nat Metab. 2021 Apr 8. doi: 10.1038/s42255-021-00378-8
Jackson CB, Turnbull DM, Minczuk M, Gammage PA. Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective. Trends in Molecular Medicine. 2020; 26: 698-709
Gammage PA, Frezza C. Mitochondrial DNA: the overlooked oncogenome? BMC Biology. 2019;17:53.
Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Patient-Specific Brain Organoids for Modeling Mitochondrial Diseases
Prof. Alessandro Prigione from, Heinrich Heine University (HHU), Germany will talk about "Patient-Specific Brain Organoids for Modeling Mitochondrial Diseases" during the congress which will be held on October 27-29, 2021 in Berlin & Online.
Mitochondrial diseases suffer from a lack of effective animal and cellular models. This hampers our understanding of the mechanisms underlying the neuronal pathology characteristics of mitochondrial diseases. Prof. Prigione used patient-derived induced pluripotent stem cells (iPSCs) and genome engineering with CRISPR/Cas9 to develop a human model of Leigh syndrome, which is the most severe mitochondrial disease in children and is currently incurable. Using neuronal cell cultures and three-dimensional brain organoids, he discovered previously unknown mechanisms causing the disease-specific neuronal defects, and identified two potential counteracting strategies for this rare mitochondrial disease with highly unmet medical need.
For more information about the article: https://www.nature.com/articles/s41467-021-22117-z
Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
A Mitochondria-Targeted Caffeic Acid Derivative Reverts Cellular and Mitochondrial Defects in Human Skin Fibroblasts from Male Sporadic Parkinson’s Disease Patients
Dr. Paulo J. Oliveira from University of Coimbra, Portugal will join the Targeting Mitochondria 2021 congress and will present a talk entitled A Mitochondria-Targeted Caffeic Acid Derivative Reverts Cellular and Mitochondrial Defects in Human Skin Fibroblasts from Male Sporadic Parkinson’s Disease Patients".
Dr. Oliveira highlighted: "We are developing a lead mitochondria-targeted hydroxycinnamic acid derivative with potential use in different diseases with a mitochondrial dysfunction component. This talk will focus on our recent study investigating the effects of our novel molecule on skin fibroblasts from sporadic Parkinson's Disease (PD) patients. Our data shows a positive impact of this molecule on mitochondrial function and redox signaling, paving the way to further in vivo studies to validate this molecule in a PD model".
Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com
Welcome to Targeting Mitochondria 2021
On behalf of the Scientific Committee of the World Mitochondria Society (WMS) we are excited to announce that the 12th Conference on Targeting Mitochondria for October 27-29, 2021 will be held as an Interactive Online Congress with live slots where many discussions and networking will unite all speakers, presenters and attendees.
On this occasion I would like to state frankly that the success of our virtual congress exceeded my expectations. From the numerous feedbacks we have received I can conclude that COVID-19 was unable to diminish our enthusiasm for the cell organelle we all revere so much. Even more, the special online format we chose seemed to have provided some unexpected benefits. For example, there was no Session Chair who had to enforce any schedule, which allowed for more extensive discussion sections as appreciated by many of us. Further, the availability of all conference contributions for an extended period of time was certainly also a very valuable feature of our 11th conference. Nevertheless, one of the most important aspects of any scientific meeting was missing, which is the personal interaction with colleagues from around the world, be it in the lecture hall, or during the coffee break or last but not least during our conference dinner. Therefore we all are very much looking forward to the next, the 12th edition of our conference series.
Independent on its format, any conference can only be as good as its speakers and its organizers. Knowing that the Organizing Committee under Prof. Marvin Edeas’ leadership will again excel in setting up the next conference, and knowing that the Scientific Committee will again invite key players in the field of Mitochondrial Medicine I assure anyone who is going to join us in this year's Interactive Online Congress on October 2021 that you won’t be disappointed, excellent interactive platform, again excellent speakers and again an excellent organization!
While we have just started working on the outline of our next conference edition, I believe that the overarching themes of our 12th World Congress on Targeting Mitochondria will not significantly deviate from topics discussed at preceding editions of our conference series. Again, we will focus on three major areas, which are first the role of mitochondrial dysfunction in etiology and pathogenesis of chronic diseases including aging, second how to assess and above all quantify mitochondrial dysfunction in vitro and in vivo and finally, third, how to target and manipulate mitochondrial function in order to develop future mitochondria-based therapies. However, we will also try to further extend the profile and scope of our conference by inviting researchers who have never participated in our meeting before, established and new investigators alike.
Basic scientists working at the bench in the laboratory, physicians treating patients suffering from mitochondrial disorders as well as representatives of companies working on the commercialization of mitochondria-targeted therapies are all welcome to our conference. We strongly believe that our 12th World Congress on Targeting Mitochondria will be at least as exciting and as successful as our virtual 11th conference. Please feel free to contact us at any time for further information and with questions you might have.
All our warmest regards.
Prof. Volkmar Weissig
President of the World Mitochondria Society
Midwestern University, USA
Online Workshop - How to Evaluate Mitochondria Function ?
The aim of this workshop is to discuss the last advances in mitochondria assessment and evaluation. The workshop will be interactive and will be recorded.
if you wish to have a short talk during the workshop, please contact us.
Neurodegeneration and Mitochondria
Prof. Ming Guo from UCLA David Geffen School of Medicine, USA will join the Targeting Mitochondria 2020 Congress which will be held in Berlin, Germany on October 29-30, 2020 and present her research during the talk entitled "Neurodegeneration and Mitochondria".
Summary of the Talk: Mitochondrial dysfunction has emerged as a common shared mechanism across multiple neurodegenerative disorders. This includes Parkinson’s disease, myopathy/frontotemporal dementia and ALS. The talk will discuss the latest research regarding these areas.
Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Virtual Congress
www.mitochondria-site.com
Mitochondria Devices: New Methods to Detect Mitochondria Dysfunction
Dr. Naïg Gueguen from MitoVasc Institute, Angers University Hospital Center, France will give a presentation entitled "Mitochondria Devices: New Methods to Detect Mitochondria Dysfunction" during the Targeting Mitochondria 2020 Congress which will be organized virtually, on October 29-30, 2020.
Summary of the presentation: Alterations in bioenergetics metabolism represent a common clue in the pathogenesis of several diseases, including metabolic disorders, neurodegenerative disease, inflammatory conditions and cancer. Progress toward deciphering the precise role of the mitochondria in disease etiology requires tools and methods that can dissect the complex interplay between multiple enzymes and oxidative pathways that act cooperatively to regenerate ATP and sustain cellular biosynthesis needs. Recent developments in respirometry, coupled to fluorometry/luminescence, allow multiplexing measurements and provide now routine analyses of a variety of processes, including metabolic rewiring, substrate supply pathways, the activities of the different respiratory chain complexes, ATP synthesis or proton leak. In this context, the choice of the relevant experimental model and design are key elements for the identification and quantification of mitochondrial dysfunctions.
Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Virtual Congress
www.targeting-mitochondria.com
More Articles...
- The Cell-free respiratory Competent Mitochondria in Blood: Strategic Role and Application
- Mitochondrial disease community registry (MDCR): Perspectives from patients and families, lessons learned from the data
- Down Syndrome: Role of hydrogen sulfide overproduction in the pathogenesis of mitochondrial dysfunction
- Mitochondrial Dysfunction in Autism is Distinct from Mitochondrial Disease
