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Inside Extreme Longevity: The First Multi-Omics Portrait of a Supercentenarian

Supercentenarian multi-omics study on extreme human longevity

A groundbreaking study published in Cell Reports Medicine offers the most comprehensive molecular characterization to date of an individual with extreme human longevity. The study, authored by Eloy Santos-Pujol and led by Manel Esteller, from Josep Carreras Leukaemia Research Institute (IJC) and Universitat de Barcelona, provides fresh insights into the biological and lifestyle factors linked to healthy aging.
What the study found:

  • Researchers performed a multi-omics analysis, including genome, transcriptome, metabolome, proteome, epigenome, and microbiome, on the person with the most extreme documented human lifespan.
  • Despite displaying traditional molecular signs of aging, such as telomere shortening, this individual avoided common age-related diseases, highlighting a “longevity paradox”.
  • Protective features included rare genetic variants, efficient lipid metabolism, low inflammation, a rejuvenated gut microbiome, and a biologically younger epigenetic profile, all linked to an extended lifespan.

Why this research matters:

This study represents a major step forward in longevity science by demonstrating that healthy aging results from the integration of molecular, biological, and lifestyle factors, rather than isolated biomarkers.

Read the full article.

We are pleased to remind you that the World Mitochondria Society (WMS), in collaboration with the International Society of Microbiota (ISM), is organizing the Targeting Longevity World Congress 2026, taking place on April 8–9 in Berlin, Germany. You can register here.

 

Now Available: Targeting Mitochondria 2025 – Book of Abstracts

Abstracts Book 2025 small 

Discover the full scientific depth of the 16th World Congress on Targeting Mitochondria, now available online.
This comprehensive volume brings together all major presentations, short oral communications, and poster abstracts — offering a complete overview of the latest advances in mitochondrial research and medicine.

From mitochondrial dynamics, transplantation, and bioenergetics, to organelle communication, AI-powered imaging, and therapeutic strategies, the Book of Abstracts reflects the diversity and creativity of our global mitochondrial community.

 Purchase Abstracts Book

Industrial & Institutional Attendees Targeting Mitochondria 2025

Industrials

Nanolive, Switzerland (Sponsor)
Lucid Scientific, USA (Sponsor)

Aardvark Therapeutics
Altos Labs UK
Biotech Investor
CellSpex Ltd
Colossal Biosciences
Crab Sinergy Srl
Dr. Mühlhausen
EK PA
HAW Albstadt-Sigmaringen
IDI IRCCS- Fondazione Maria Luigi Monti
IRCCS San Raffaele Scientific Institute
The International Space Federation (ISF)
Throne Biotechnologies

Kyowa Kirin
Labryo Fertility Center
L'Oreal R&I
Lunella Biotech. Inc.,
Michael J Fox Foundation
Minovia Therapeutics Ltd.
Neurim Pharamceuticals
Novartis Biomedical Research
Practice for Internal Medicine
Proya Europe
Solid Biosciences
The Roger Williams Institute of Liver Studies
UT Texas MD Anderson Cancer Center
Vertex Pharmaceuticals

Lithuanian University of Health Sciences
Mariateresa Volpicella
Maastricht University
National Cerebral and Cardiovascular Center Research Institute
National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad
National Research Council (CNR)
National University of Singapore
Nazarbayev University
Nencki Institute of Experimental Biology
Nencki Institute of Experimental Biology PAS
No affiliation
Northumbria University, Newcastle University
Okayama University
ORBI team, URBC, University of Namur
Polytechnic University of Marche
Radboud University Department of Microbiology
RNA Biology of the Neuron Unit (Cioni Lab)
Seoul National University College of Medicine
Shanghai jiaotong university
Sheba Medical Center
Stanford University
Stellenbosch University
Stockholm Univerisity
Tampere University
The University of Melbourne
Tokyo University of Science
UCLouvain  -LTAP
UMC Utrecht
Universitätsklinikum Essen
Universidad de Castilla La-Mancha
Universidad de Guanajuato 
and more... Last Updated October 2

Read more...

Scientific Partner - Biomedical Data

Biomedical Data Logo 3

The World Mitochondria Society welcomes Biomedical Data as a scientific supporter of the 16th World Mitochondria Society Congress, taking place from October 22–24, 2025, in Berlin, Germany.

Biomedical Data is a company specialized in statistical consulting for biomedical and scientific research. We work with physicians, researchers, postgraduate and PhD students, health science graduates, biochemists, biologists, and companies. Our services include:

  • Sample Size Calculation
  • Inferential Statistics
  • Descriptive and Exploratory Statistics
  • Publication and Conference Assistance
  • Multivariate Analysis
  • Data Cleansing & Curation

Our goal is to provide accurate, reliable, and insightful data analysis to support high-quality, evidence-based conclusions.

Website: biomedical-data.com

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Targeting Mitochondria 2026 Venue

DoubleTree Hilton Berlin

The 17th World Congress on Targeting Mitochondria on October 21-23, 2026, at

DoubleTree by Hilton Berlin Ku'damm
Los-Angeles-Platz 1
10789 Berlin, Germany

Book your king guest room – including breakfast with tax

(Special rate room only applies for a 2-day meeting + extra night, from October 21 to 23, please choose within these dates to get the special rate room)


How to Reach DoubleTree by Hilton:

1. From Berlin Tegel Airport (TXL):

  • By Taxi: Taxis are readily available outside the terminal. The journey takes approximately 15-20 minutes, depending on traffic.
  • By Public Transport: Take the X9 bus towards Zoologischer Garten. The hotel is a short walk from there.

2. From Berlin Schönefeld Airport (SXF):

  • By Taxi: Taxis are readily available outside the terminal. The journey takes approximately 30-40 minutes, depending on traffic.
  • By Public Transport: Take the regional train RE7 or RB14 to Zoologischer Garten, then a 10-minute walk.

3. By Train from Berlin Hauptbahnhof:

  • Take S-Bahn lines S3, S5, S7, or S9 to Zoologischer Garten, then a brief walk.

4. By Car:

  • The hotel is near the A100 city motorway.
  • Parking is available at the hotel for a fee.

5. Public Transportation:

  • U2 subway line stops at U-Bahnhof Zoologischer Garten.
  • Numerous bus lines stop nearby.

World Mitochondria Society
17th Targeting Mitochondria 2026 Congress
October 21-23, 2026 - Berlin, Germany 
www.wms-site.com